Answer Study

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Let's clear up the facts

Combination treatment has the potential to improve outcomes. For this study, we added Oracea® (doxycycline, USP) 40mg Capsules to Soolantra® (ivermectin) Cream, 1% to measure efficacy and ensure the treatment approach aims for 'clear'.1 Clear is defined as IGA score of 0 according to the IGA (Investigator Global Assessment) scale, which is commonly used by dermatologists.

Both molecules have independent and cooperative effects on the inflammatory pathways of rosacea.

Soolantra® (ivermectin) Cream tube and Oracea® (doxycycline, USP) Capsules bottle

Understanding the Importance of Clear Skin CLEAR* Analysis: Overview2

Post-hoc analysis of Phase 2 and Phase 3 studies of Soolantra Cream

OBJECTIVE: Define the benefit of being "clear" versus "almost clear" in subjects considered a "success" with treatment

All subjects who achieved clear (IGA=0) or almost clear (IGA=1) were combined regardless of treatment (Soolantra Cream and MetroCream Topical Cream, 0.75%) and vehicle

*CLEAR = Change the Level of Expectation of Achievement for Rosacea


Subjects Who Achieve Clear Remain Treatment Free for 5 Months Longer Than Subjects Who Achieve Almost Clear12

Chart showing the pooled analysis of treatment-free time after treatment for rosacea. The median time to treatment (relapse) for patients who achieved almost clear was 3 months and for patients who achieved clear was >8 months.

*Pooled post-hoc analysis of 4 studies evaluating Soolantra Cream 1%, MetroCream Topical Cream, 0.75%, or vehicle in subjects with inflammatory papules and pustules of rosacea.


"Clear" subjects reported a better improvement of their rosacea versus "almost clear" subjects (76.8% vs 41.8% with excellent improvement)2

Graph showing the percentage of patients reporting either no improvement, moderate improvement, good improvement, or excellent improvement of their rosacea.

  • Overall, "clear: subjects had a better improvement in their rosacea compared with "almost clear" subjects
  • 76.8% "clear" subjects indicated they had excellent improvement
  • Only 41.8% of "almost clear" subjects indicated they had excellent improvement