Let's clear up the facts
Combination treatment has the potential to improve outcomes. For this study, we added Oracea® (doxycycline, USP) 40mg Capsules to Soolantra® (ivermectin) Cream, 1% to measure efficacy and ensure the treatment approach aims for 'clear'.1 Clear is defined as IGA score of 0 according to the IGA (Investigator Global Assessment) scale, which is commonly used by dermatologists.
Both molecules have independent and cooperative effects on the inflammatory pathways of rosacea.
Understanding the Importance of Clear Skin CLEAR* Analysis: Overview2
Post-hoc analysis of Phase 2 and Phase 3 studies of Soolantra Cream
All subjects who achieved clear (IGA=0) or almost clear (IGA=1) were combined regardless of treatment (Soolantra Cream and MetroCream Topical Cream, 0.75%) and vehicle
*CLEAR = Change the Level of Expectation of Achievement for Rosacea
Subjects Who Achieve Clear Remain Treatment Free for 5 Months Longer Than Subjects Who Achieve Almost Clear12
*Pooled post-hoc analysis of 4 studies evaluating Soolantra Cream 1%, MetroCream Topical Cream, 0.75%, or vehicle in subjects with inflammatory papules and pustules of rosacea.
"Clear" subjects reported a better improvement of their rosacea versus "almost clear" subjects (76.8% vs 41.8% with excellent improvement)2
- Overall, "clear: subjects had a better improvement in their rosacea compared with "almost clear" subjects
- 76.8% "clear" subjects indicated they had excellent improvement
- Only 41.8% of "almost clear" subjects indicated they had excellent improvement